Dofetilide mathematical model
Webtheir reinduction (Tikosyn [dofetilide] capsules package insert; Pfizer, Inc). Dofetilide is important among the antiarrhythmics for multiple reasons. It is one of the most effective … WebJul 1, 2005 · The in vitro affinity and activity of dofetilide were determined in recombinant cell cultures expressing the hERG channel, and the QT-prolonging effect of dofetilide was assessed in 5 clinical...
Dofetilide mathematical model
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WebTIKOSYN (dofetilide) increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. This effect, and the related increase in effective refractory period, is observed in the atria and ventricles in both resting and paced electrophysiology studies. WebApr 4, 2024 · What is dofetilide? Dofetilide is a heart rhythm medicine, also called an antiarrhythmic. Dofetilide is used to help keep the heart beating normally in people with …
WebOct 13, 2024 · Figure 3. Mathematical models based on the model parameters Based on the definition of the model parameters. Deterministic models are the models where each parameter is defined in an unambiguous ... WebMar 9, 2024 · Those treated with dofetilide had the highest proportion of patients prescribed an anticoagulant (68%), and those treated with amiodarone had the lowest proportion of patients prescribed an …
WebApr 4, 2024 · CrCl greater than 60 mL/min: 500 mcg orally twice a day. CrCl 40 to 60 mL/min: 250 mcg orally twice a day. CrCl 20 to less than 40 mL/min: 125 mcg orally … WebApr 11, 2024 · Long QT syndrome type 1 with affected IKs is associated with a high risk for developing Torsade de Pointes (TdP) arrhythmias and eventually sudden cardiac death. Therefore, it is of high interest to explore drugs that target IKs as antiarrhythmics. We examined the antiarrhythmic effect of IKs channel activator ML277 in the chronic …
WebNOTE: Dosage adjustments based on determinations of renal function are critically important. The manufacturer recommends using actual body weight in the Cockcroft …
WebThe QTc interval versus dofetilide plasma concentration was analyzed by use of pharmacokinetic and pharmacodynamic modeling techniques. Results: Dofetilide absolute bioavailability and systemic clearance were 92% +/- 9% and 0.35 +/- 0.05 L/hr/kg, respectively. Mean maximum increase in QTc interval duration was 99 msec (27%) and … metal border fence sectionsWebTo characterise the pharmacokinetics of dofetilide in patients and to identify clinically relevant parameter-covariate relationships. To investigate three different modelling strategies in covariate model building using dofetilide as an example: (1) using statistical criteria only or in combination with clinical irrelevance criteria for covariate selection, (2) … how the aurora is formedWebSep 16, 2010 · A Computer Modeling Study Abstract: Dofetilide is a class-Ill drug that inhibits the rapid component of the delayed potassium current (I Kr ). Experimental studies have shown that the different layers of ventricular muscle present differences in action potential duration (APD) and different responses to class III agents. how the author develops the key conceptWebDofetilide C19H27N3O5S2 CID 71329 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... how the australian voting system worksWebSaline (control), dofetilide, ranolazine, or a combination of dofetilide and ranolazine was administered in four incremental doses. Atrial fibrillatory activity was extracted from surface ECGs using spatiotemporal QRST cancellation. The mean atrial fibrillatory rate before drug infusion was 297 ± 27 fpm. metal boot trayWebApr 7, 2024 · Dofetilide selectively inhibits the rapid component of the delayed potassium current (IKr). In this work, a mathematical model of dofetilide effects on … metal boots in a one peice gameDofetilide is metabolized predominantly by CYP3A4 enzymes predominantly in the liver and GI tract. This means that it is likely to interact with drugs that inhibit CYP3A4, such as erythromycin , clarithromycin , or ketoconazole , resulting in higher and potentially toxic levels of dofetilide. See more Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 µg of dofetilide. It is not available in Europe … See more Prior to administration of the first dose, the corrected QT (QTc) must be determined. If the QTc is greater than 440 msec (or 500 msec in patients with ventricular conduction abnormalities See more Mechanism of action Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (IKr). This causes the … See more • Antiarrhythmic agents • Cardiac action potential • Electrocardiogram See more Dofetilide is used for the maintenance of sinus rhythm in individuals prone to the occurrence of atrial fibrillation and flutter arrhythmias, and for chemical cardioversion to … See more Torsades de pointes is the most serious side effect of dofetilide therapy. The incidence of torsades de pointes is 0.3-10.5% and is dose … See more After its initial US FDA approval, due to the pro-arrhythmic potential it was only made available to hospitals and prescribers that … See more metal boots football