2024 Intratracheal administration in rats

Intratracheal administration in rats

Author: ivhi

August undefined, 2024

WebThe suspensions of Nano-TiO 2 were sonicated for 20 minutes and administrated to rats via one intratracheal injection at a dose of 0.6 mL/200 g body weight, respectively. 28 Rats in the control group were instilled with 0.6 mL PBS per 200 g body-weight. Before injection, the rats were anesthetized by ether. Food and water were provided 2 hours ... WebTreatment of the rats was performed 5 days/week for 28 days, always between 8 and 10 am. The suspension of TiO 2 NPs was applied by intratracheal instillation (1 mL/kg BW volume) with brief anesthesia. 34 Rat BW was measured every morning before treatment to determine the exact daily dose to be instilled and to see the effect of treatment on BW …

(PDF) Comparative Characterization of Lung Muscarinic

WebSep 21, 2024 · It was observed that repeated intra-tracheal administration of high-dose rifampicin (up to 50 mg/kg) powder formulations were safe to rat lungs and liver, and intra-tracheal rifampicin decreased the drug burden on the liver compared to oral rifampicin, as suggested by no rise in the serum alanine transaminase (ALT) activity in repeated dose … WebApr 10, 2024 · The mouse model of ALI was established by intratracheal administration of LPS from E. coli at a dose of 10 mg/kg body weight, while intratracheal LPS administration at a dose of 20 mg/kg body weight was employed in survival studies, since intratracheal injection with a low dose of LPS could induce lung injury only and was not … layered baked ziti meatless

Pulmonary clearance kinetics and extrapulmonary translocation …

WebJul 25, 2024 · 10.3791/61469-v. Dry powder formulations for inhalation have great potential in treating respiratory diseases. Before entering human studies, it is necessary to evaluate the efficacy of the dry powder formulation in preclinical studies. A simple and noninvasive method of the administration of dry powder in mice through the intratracheal route ... Webcomplicated equipmentÐ the insertion of a relatively wide tube into the trachea of rats, allowing drug administration. Keywords Endotracheal intubation; rat; large tube; intratracheal aerosol drug administration Endotracheal intubation in small laboratory … WebFeb 1, 2011 · Intratracheal administration of tiotropium (0.6-6.4 nmol/kg) caused sustained (lasting at least 24 h) increase in the apparent dissociation constant (K(d)) for [(3)H]NMS binding in rat lung ... layered baked french toast

A method for intratracheal instillation in the rat - PubMed

The oral and intratracheal toxicities of ROUNDUP and its components to rats

WebIn vivo techniques: Administration of test compounds via multiple routes: IV, IP, SC, oral gavage, intratracheal, intrathecal, intranasal; rodent brain stereotaxic surgery; blood collection ... WebEffects of maternal retinoic acid administration on lung angiogenesis in oligohydramnios-exposed fetal rats. / Chen, Chung Ming ; Chou, Hsiu Chu ; Wang, Leng-Fang 等. 於: Pediatrics and Neonatology , 卷 54, 編號 2, 04.2013, p. 88-94. layered baked zitiWebPurpose. To evaluate the intratracheal route of administration as an alternative to oral administration for 2′,3′-dideoxyinosine (ddI). Methods. A ddI dose (40 mg/kg/300 µl or 6.5 mg/kg/50 µl) was instilled into the trachea in female Fisher rats and an intravenous tracer dose (9 µg/kg) of 3H-ddI was administered concomitantly to determine the drug … layered ballistic gel

"WebApr 8, 2024 · The intratracheal exposure consists at introducing the same solution directly into the trachea. The mouse is lying supine on a platform inclined at 45º, hanging stably … " - Intratracheal administration in rats

Intratracheal administration in rats

Repurposing of carvedilol to alleviate lung fibrosis in rats ...

WebA method was developed to provide safe, rapid, and accurate intratracheal instillation of radionuclides into the rat lung. Rats were anesthetized with halothane and suspended … WebMay 4, 2024 · Therefore, intratracheal administration of stem cells and combined surfactant and glucocorticoid treatment has emerged as a new strategy to treat …

Did you know?

WebOct 15, 2014 · The effect of intratracheal administration of cyclooxygenase-1 (COX-1)-modified adipose stem cells (ASCs) on monocrotaline-induced pulmonary hypertension … WebAug 11, 2024 · In rats with BPD, the authors compared the intratracheal administration of either hUC-MSC exosomes, hUC-MSCs, or hUC-MSC VEGF knockdown exosomes transfected with siRNA . Ahn et al. found that MSCs and MSC-derived EVs, but not EVs derived from VEGF knockdown MSCs, were able to attenuate the degree of cell death, …

WebMay 1, 2024 · At birth, rats were distributed in three groups: (a) animals raised in ambient air for 6 weeks (n = 10); and animals exposed to 60% hyperoxia for 2 weeks and to room … WebFeb 8, 2013 · This study compares intratracheal bolus instillation (IT) with dose-adjusted ae … Lipopolysaccharide-induced acute lung injury in rats: comparative assessment of …

WebDec 20, 2024 · We investigated the effects of intratracheal administration of autologous BMCs on MCT-induced pulmonary vessel remodeling and lung inflammation in rats. Methods All animal experiments were approved by the University of the Ryukyus Institutional Animal Care and Use Committee, and were performed in accordance with the National … WebTo provide a toxicity test method which enables cheaply and simply evaluating the inhalation toxicity of chemicals, and a toxicity test kit. The toxicity test method in one embodiment involves a, b and c below. a: Calculate the use amount α of a test substance from the survival rate of the cells when the cells have been cultured using a culture fluid that …

WebDu Z, Zhao D, Jing L, et al. Cardiovascular toxicity of different sizes amorphous silica nanoparticles in rats after intratracheal instillation. Cardiovasc Toxicol. 2013;13(3) ...

WebThe suspensions of Nano-TiO 2 were sonicated for 20 minutes and administrated to rats via one intratracheal injection at a dose of 0.6 mL/200 g body weight, respectively. 28 Rats … layered baked ziti with ricotta cheeseWebSep 15, 2012 · Endotracheal intubation of rats with a probe which generates powder aerosols enables controlled administration of drug directly into the respiratory tract. However, preliminary observations of intratracheal powder administration procedures have raised concerns with regard to pulmonary safety. layered baked ziti with ricottaWebJan 22, 2008 · After intratracheal administration of Man-7.5 and Man-5.0-liposomes in rats, a significantly high internalization and selective targeting to alveolar macrophages … layered ball gownWeb1 day ago · Idiopathic pulmonary fibrosis (IPF) is the most widely studied interstitial lung disease. IPF eventually leads to respiratory insufficiency, lung canc… katherine heigl tom cruiseWebGavage needles come in various sizes and lengths. The correct needle or cannula length is equal to the distance from the mouth to the last rib. The recommended maximum volume for administration is 1% of body weight (e.g., a 20 gm mouse can be given 0.2 ml). Correct restraint technique is critical for successful oral gavage. layered ball gown wedding dressWebThis policy addresses issues related to administration of compounds within a protocol with the goal of facilitating the procedure for the person administering the compound as well … katherine heines therapyWebAfter establishing a pulmonary fibrosis model via the intratracheal administration of bleomycin (BLM) to 8-week-old mice, MSCs derived from human umbilical cords were administered intravenously or intratracheally on day 10 and the lungs were immunologically analyzed on days 14 and 21. layered banana pineapple dessert