Web029099 FVB/NJ-Tg(C9orf72)500Lpwr/J The C9-500 BAC transgenic mouse line expresses a human C9orf72 gene with ~500 hexanucleotide repeats. This may be useful for studying C9orf72 repeat length-dependent gain-of-toxicity in familial amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD). Please note : The ALS ... WebElevations in soluble Complement 5b-9 (sC5b-9) have been associated with increased activation of the alternative complement pathway. Increased complement activation may be seen with aHUS and other TMAs, and may be a sensitive early predictor of the development of transplant associated TMA. In a cohort of 67 pediatric patients who had an ...
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